|
KMID : 0368819960350040790
|
|
Journal of the Korean Neuropsychiatr Association
1996 Volume.35 No. 4 p.790 ~ p.797
|
|
|
Interleukin-2(II-2) Productivity in Schizophrenic Patients
|
|
김경용
김임/박주홍/은헌정/김동인/이선미
|
|
|
Abstract
|
|
|
Objects:
@EN This study was designed to examine the decreased cellular immune response and the change in cellular immunity related to clinical status in Korean schizophrenic patients.
@ES Method:
@EN The subjects were 19 acute schizophrenics and 21 remitted schizophrenics who met the DSM-IV criteria of schizophrenia and 40 healthy volunteers as the normal control After the lymphocyte was separated from blood which had been drawn from the
subjects and then T lymphocyte was stimulated by PHA and proliferated by cell culture, the examiner measured IL-2 productivity by IL-2 immunoassay kit.
@ES Results:
@EN IL-2 productivity of the schizophrenics was significantly lower than that of the normal controls. There was no significant difference between male and female in two groups. In the comparison by clinical status, acute schizophrenic group was
next,
and normal control group was the highest in the IL-2 productivity, with statistically significant difference among the groups(p<0.001).
@ES Conclusion:
@EN We suggest that there is a decrease in the cellular immune response which is significantly related to clinical status in some Korean schizophrenics. This finding supports that onset of schizophrenia may be the result of autoimmune mechanism,
which
is one of the various etiologic factors in schizophrenia.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|